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GLP-1s, or Glucagon-Like Peptide-1 receptor agonists, are prescription medications used to treat type 2 diabetes and, in some cases, obesity. These drugs mimic the action of a natural hormone called Glucagon-Like Peptide-1 (GLP-1) that is produced in the intestines in response to food intake. GLP-1 is responsible for regulating blood sugar levels by stimulating the release of insulin and inhibiting the release of glucagon, another hormone that raises blood sugar levels.

GLP-1 receptor agonists work by binding to the GLP-1 receptors on cells in the pancreas and other tissues, which helps to:

1. Increase insulin secretion: GLP-1s promote the release of insulin from the pancreas, which lowers blood sugar levels after eating.

2. Decrease glucagon secretion: They also inhibit the release of glucagon, a hormone that raises blood sugar levels by promoting the release of glucose from the liver.

3. Slow gastric emptying: GLP-1s slow down the emptying of the stomach, which can help reduce post-meal spikes in blood sugar levels.

4. Promote a feeling of fullness: GLP-1 receptor agonists can help reduce appetite and promote weight loss by making individuals feel full, which is why they are used to treat obesity.

Currently there are three GLP-1s approved by the FDA for weight management: liraglutide (Saxenda), semaglutide (Wegovy), and tirzepatide (Zepbound).

GLP-1 receptor agonists are typically administered by injection, either once a day, once a week, or once a month, depending on the specific medication.

GLP-1 receptor agonists are considered an important addition to the treatment options for people with type 2 diabetes, as they can help improve blood sugar control, support weight loss, and have a low risk of causing low blood sugar (hypoglycemia). However, like all medications, they may have side effects, so Companion will help to determine the most appropriate treatment plan for your specific needs.

Compounded GLP-1 Medications are patient-specific medications created in a state Board of Pharmacy or FDA licensed compounding facility per a prescription from a licensed healthcare professional. Compounded drugs are required to exclusively use ingredients from FDA-licensed facilities, and test sterile compounds for potency, sterility, and purity.

While compounded drugs are legal they do not undergo pre-market approval from the FDA as they are not made in large batches for the public, compounds are made based on specific orders from a medical professional. Because of that the dose, route of administration, and efficacy may differ from commercially available, brand-name, drugs.
Companion works with licensed sterile compounding pharmacies in the United States.

Get started by scheduling your complimentary consultation here.

Our physician will work with you to determine the best treatment options and can prescribe weight loss medications to those who qualify.

We do not accept insurance at this time. We can, however, assist you with checking your insurance to see if you have coverage for name brand prescriptions. 

Cost depends on the type of insurance you have and the medication. Newer generation medications like GLP-1s can be very expensive ($900-$1200 a month in the U.S. if you’re paying out-of-pocket), and insurance companies vary greatly on which medications they cover, if any. Coupons and other options may be available.

We can assist you with checking your insurance to see if you have coverage for name-brand prescriptions.

Compounded medications are an option without insurance coverage.

The amount of weight you can lose on a GLP-1 can range from 5% to over 20% depending on which medication you’re taking. Newer second-generation medications like Wegovy and Mounjaro show more weight loss

The FDA has approved weight-management medications like GLP-1s for individuals living with obesity, which is defined as having a body mass index (BMI) of 30 or above and people with a BMI of 27 and above with health conditions. It is ultimately up to a health care provider to determine who is eligible. Our provider will work with you to determine your best treatment plan. 

Like all medications, those designed for weight loss have the potential for side effects. Side effects can vary depending on the medication, dose, and individual. GLP-1 medications tend to be mild and improve as you continue taking the medication. The most common side effects include GI issues (nausea, diarrhea, constipation, vomiting,  stomach pain), headaches, and sleep disturbances. We will work with you to minimize side effects.

Currently, we are only available for telehealth patients in Missouri. We can see patients from other states in our office in St Louis. Keep checking back as we add more locations.